Genomic aberrations in human hepatoblastomas detected by 2-dimensional gel analysis

摘要: Abstract Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means restriction landmark scanning (I. Hatada et al. , Proc. Natl. Acad. Sci. USA, 88: 9523–9527, 1991). About 2000 Not I landmarks were monitored each the hepatoblastomas, which revealed that intensity eight spots decreased genome, suggesting allelic loss. Three these identical to those human hepatocellular carcinomas. These results suggested common, early events are involved genesis two types liver tumor.