Genetic variations in recurrent astrocytic tumors detected by restriction landmark genomic scanning.
作者： Takuo Inui , Yoshio Hiasa , Hisaki Nagai , Shigeru Tsunoda , Hiroyuki Nakase
DOI: 10.1007/BF02482093
关键词:
摘要: The genetic mechanisms associated with recurrence of advanced astrocytic tumors are poorly understood. We therefore analyzed 24 biopsy specimens from 12 patients a recurrent tumor by two-dimensional gel electrophoresis method, termed restriction landmark genomic scanning (RLGS). Four spot changes were commonly present in the primary astrocytomas, indicating that corresponding gene alterations early events development this type. Altered spots more frequent and different distribution than astrocytomas. In particular, specifically increased intensity for on chromosomes 9–12 18 reduced observed secondary tumors, suggesting relation recurrence. same also found respective lesions but strikingly densities some cases, instability. altered segments provide important candidate regions search genes involved leading to progression malignant tumors.
springer.com
sci-hub.se 参考文章(34)
Mitsutoshi Nakamura, Noboru Konishi, Shigeru Tsunoda, Yoshio Hiasa, Toshihide Tsuzuki, Hideo Aoki, Kunihiko Kobitsu, Hisaki Nagai, Toshisuke Sakaki, Analyses of human gliomas by restriction landmark genomic scanning. Journal of Neuro-oncology. ,vol. 35, pp. 113- 120 ,(1997) , 10.1023/A:1005712308061
Andreas von Deimling, Jennifer A. Burwick, David K. Lisle, Jonathan E. Rosenberg, David N. Louis, Harvey W. Mohrenweiser, Keisuke Ueki, Refined deletion mapping of the chromosome 19q glioma tumor suppressor gene to the D19S412-STD interval. Oncogene. ,vol. 13, pp. 2483- 2485 ,(1996)
Mitsutoshi Nakamura, Noboru Konishi, Shigeru Tsunoda, Yoshio Hiasa, Toshihide Tsuzuki, Kiyoshi Takemura, Kunihiko Kobitsu, Toshisuke Sakaki, Genomic alterations in human glioma cell lines detected by restriction landmark genomic scanning Journal of Neuro-oncology. ,vol. 34, pp. 203- 209 ,(1997) , 10.1023/A:1005714811327
McLendon Re, Bigner Dd, Fuchs He, Friedman Ah, Rasheed Bk, Bigner Sh, Friedman Hs, Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene. ,vol. 10, pp. 2243- 2246 ,(1995)
N Konishi, Y Hiasa, M Nakamura, Y Kitahori, K Matsubara, H Nagai, Different patterns of DNA alterations detected by restriction landmark genomic scanning in heterogeneous prostate carcinomas. American Journal of Pathology. ,vol. 150, pp. 305- 314 ,(1997)
G Reifenberger, K Ichimura, V P Collins, E E Schmidt, CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Research. ,vol. 54, pp. 6321- 6324 ,(1994)
Masami Muramatsu, Yoshihide Hayashizaki, Yasushi Okazaki, William A. Held, Hisato Okuizumi, Hideaki Konno, Tomoya O. Akama, Mitsuteru Ito, Christoph Plass, Restriction Landmark Genomic Scanning (RLGS-M)-based Genome-wide Scanning of Mouse Liver Tumors for Alterations in DNA Methylation Status Cancer Research. ,vol. 57, pp. 3294- 3299 ,(1997)
Hiroshi Kanno, Isao Yamamoto, Masahiro Yao, Keiichi Kondo, Taro Shuin, Masamichi Shinonaga, Susumu Ito, Minoru Yoshida, Somatic mutations of the von Hippel-Lindau tumor suppressor gene and loss of heterozygosity on chromosome 3p in human glial tumors. Cancer Research. ,vol. 57, pp. 1035- 1038 ,(1997)
Peter A. Jones, DNA Methylation Errors and Cancer Cancer Research. ,vol. 56, pp. 2463- 2467 ,(1996)
Richard M. Cawthon, Carolyn A. Pedone, Douglas Brockmeyer, Dan Fults, Micam W. Tullous, p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Research. ,vol. 52, pp. 674- 679 ,(1992)