Inhibition of EGFR signaling: all mutations are not created equal.
作者： Adi F Gazdar , John D Minna
DOI: 10.1371/JOURNAL.PMED.0020377
关键词: Carcinogenesis 、 Point mutation 、 Mutation 、 Multicellular organism 、 Signal transduction 、 Cancer research 、 Insertion 、 Tyrosine kinase 、 Biology 、 Receptor
摘要: Tyrosine kinases (TKs) are found only in metazoans, where they regulate multiple critical multicellular functions, including growth, differentiation, apoptosis, adhesion, and mobility [ 1]. As these functions also play roles tumorigenesis, TKs the prototypical class of oncogenes involved many human malignancies. Of 90 TKs, 58 receptor grouped into 20 subfamilies, while others non-receptor ten subfamilies.
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