Basic Approaches in Anatomic Toxicologic Pathology
作者： E. Terence Adams , Torrie A. Crabbs
DOI: 10.1016/B978-0-12-415759-0.00006-6
关键词: Protocol (science) 、 Pathology 、 Documentation 、 Medicine 、 Animal Welfare (journal) 、 Organ weight
摘要: This chapter provides a basic overview of the multiple aspects and considerations that impact proper conduct regulatory toxicologic pathology studies. The introduces novice pathologist to topics include, but are not limited to, Good Laboratory Practices, animal welfare issues, necropsy processes, clinical chemistry data, organ weight tissue fixation, histology procedures, Cause Death documentation. goal is enhance awareness factors influence study protocol development interpretation in-life, gross, histomorphologic data. Regulatory also briefly discussed.
sci-hub.se 参考文章(42)
G Bjornson, D Scheifele, J Dimmick, Rapid postmortem gut autolysis in infant rats: a potential problem for investigators. Canadian Journal of Veterinary Research-revue Canadienne De Recherche Veterinaire. ,vol. 51, pp. 404- 406 ,(1987)
Kevin P Keenan, Philippe Laroque, Gordon C. Ballam, Keith A. Soper, Rakesh Dixit, Britta A. Mattson, Stephen P Adams, John B. Coleman, The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment. Toxicologic Pathology. ,vol. 24, pp. 757- 768 ,(1996) , 10.1177/019262339602400620
Birgit Kittel, Christine Ruehl-Fehlert, Gerd Morawietz, Jan Klapwijk, Michael R. Elwell, Barbara Lenz, M. Gerard O'Sullivan, Daniel R. Roth, Peter F. Wadsworth, Revised guides for organ sampling and trimming in rats and mice – Part 2 Experimental and Toxicologic Pathology. ,vol. 55, pp. 413- 431 ,(2004) , 10.1078/0940-2993-00349
Gregory M. McLarrin, Vacuoles in the Fiber Tracts of Rat CNS Tissues: A Processing Artifact Journal of Histotechnology. ,vol. 5, pp. 171- 171 ,(1982) , 10.1179/HIS.1982.5.4.171
J YOUNG, Histopathologic examination of the rat nasal cavity Toxicological Sciences. ,vol. 1, pp. 309- 312 ,(1981) , 10.1016/S0272-0590(81)80037-1
M. J. Hoenerhoff, M. F. Starost, J. M. Ward, Eosinophilic Crystalline Pneumonia as a Major Cause of Death in 129S4/SvJae Mice Veterinary Pathology. ,vol. 43, pp. 682- 688 ,(2006) , 10.1354/VP.43-5-682
L. Boone, D. Meyer, P. Cusick, D. Ennulat, A. Provencher Bolliger, N. Everds, V. Meador, G. Elliott, D. Honor, D. Bounous, H. Jordan, , Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies. Veterinary Clinical Pathology. ,vol. 34, pp. 182- 188 ,(2005) , 10.1111/J.1939-165X.2005.TB00041.X
James W. Crissman, Dawn G. Goodman, Paul K. Hildebrandt, Robert R. Maronpot, Donald A. Prater, Julia H. Riley, William J. Seaman, Daryl C. Thake, Best Practices Guideline: Toxicologic Histopathology Toxicologic Pathology. ,vol. 32, pp. 126- 131 ,(2004) , 10.1080/01926230490268756
Masayuki Kemi, Kevin P. Keenan, Carol Mccoy, Chao-Min Hoe, Keith A. Soper, Gordon C. Ballam, Matthew J. Van Zwieten, The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats. Toxicologic Pathology. ,vol. 28, pp. 285- 296 ,(2000) , 10.1177/019262330002800208
B JORTNER, The return of the dark neuron. A histological artifact complicating contemporary neurotoxicologic evaluation Neurotoxicology. ,vol. 27, pp. 628- 634 ,(2006) , 10.1016/J.NEURO.2006.03.002