Quantitative analysis of water proton spectral lineshape: a novel source of contrast in MRI

摘要: Previous work in this laboratory has demonstrated improved anatomic and functional images produced from high spectral spatial resolution (HiSS) MRI of the water proton signal. The present tests hypothesis that different Fourier components resonance represent anatomically and/or physiologically distinct populations molecules within each small image voxel. HiSS datasets were acquired tomatoes rodent tumors at 4.7 T using echo-planar spectroscopic imaging (spatial resolutions 117–150 µm 1.5–3.1 Hz, respectively). Images component (referred to as images, or FCIs) produced. FCIs frequencies offset peak ('off-peak' compared with largest amplitude, i.e. peak-height image. Results demonstrate off-peak differ significantly resonances are often asymmetric. These results show signal various frequency offsets come anatomic/physiologic environments. Off-peak a new source structural information may have clinical utility.