Tbx1 Coordinates Addition of Posterior Second Heart Field Progenitor Cells to the Arterial and Venous Poles of the Heart
作者： M. Sameer Rana , Magali Théveniau-Ruissy , Christopher De Bono , Karim Mesbah , Alexandre Francou
DOI: 10.1161/CIRCRESAHA.115.305020
关键词: DiGeorge syndrome 、 Progenitor 、 Transcriptome 、 Anatomy 、 Cardiology 、 Biology 、 Embryonic heart 、 Cardiac progenitors 、 Progenitor cell 、 TBX1 、 Internal medicine 、 Embryo
摘要: Rationale:Cardiac progenitor cells from the second heart field (SHF) contribute to rapid growth of embryonic heart, giving rise right ventricular and outflow tract (OFT) myocardium at arterial pole atrial venous pole. Recent clonal analysis cell-tracing experiments indicate that a common pool in posterior region SHF gives both OFT myocytes. The mechanisms regulating deployment this remain unknown. Objective:To evaluate role TBX1, major gene implicated congenital defects 22q11.2 deletion syndrome patients, development. Methods Results:Using transcriptome analysis, genetic tracing, fluorescent dye-labeling experiments, we show Tbx1-dependent originates Hox-expressing SHF. In Tbx1 null embryos, fail segregate cell pool, leading failure expand dorsal per...
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