Cocirculation of and coinfections with hepatitis A virus subgenotypes IIIA and IB in patients from Pune, western India.
作者： Shobha Chitambar , Madhuri Joshi , Kavita Lole , Atul Walimbe , Sunil Vaidya
DOI: 10.1111/J.1872-034X.2007.00025.X
关键词: Biology 、 Coinfection 、 Polymerase chain reaction 、 RNA polymerase 、 Molecular epidemiology 、 Genotype 、 Virology 、 Viral hepatitis 、 Hepatitis A 、 Reverse transcriptase
摘要: AIM: During the 1990s, a changing pattern of epidemiology hepatitis A was reported in different populations India. The present study undertaken to investigate molecular virus (HAV) strains over period 10 years. METHODS: Stool/serum samples were collected from patients clinically presenting acute viral and hepatic encephalopathy. Reverse transcriptase polymerase chain reaction (RT-PCR) performed detect HAV-RNA. HAV genomes examined by sequencing PCR products VP1/2A junction (168 bp) RNA (116 regions. RESULTS: Subgenotype IIIA IB detected 74.2% 9.7% specimens, respectively, while 16.1% had mixed infections. Sewage also showed presence both (9/10) (1/10) subgenotypes. region two clusters constituting 51.6% 19.4% closer Nor21 HM175 strains, clinical specimens. Three isolates appeared as discordant subgenotypes CONCLUSION: data revealed cocirculation coinfection with IB, predominance genetic heterogeneity western
sci-hub.se 参考文章(34)
SD Chitambar, SMITA Murthy-Grewal, MADHURI Bokil, VA Arankalle, MM Gore, K Banerjee, Indigenous anti-hepatitis A virus IgM capture ELISA for the diagnosis of hepatitis A. Indian Journal of Medical Research. ,vol. 99, pp. 243- 251 ,(1994)
V. A. Arankalle, S. D. Chitambar, Ashish R. Bavdekar, Anand N. Pandit, Sheila A. Bhave, Sachin V. Bendre, Fulminant hepatic failure: etiology, viral markers and outcome. Indian Pediatrics. ,vol. 36, pp. 1107- 1112 ,(1999)
M H Bachmann, C Mathiason-Dubard, G H Learn, A G Rodrigo, D L Sodora, P Mazzetti, E A Hoover, J I Mullins, Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades. Journal of Virology. ,vol. 71, pp. 4241- 4253 ,(1997) , 10.1128/JVI.71.6.4241-4253.1997
J I Cohen, J R Ticehurst, R H Purcell, A Buckler-White, B M Baroudy, Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. Journal of Virology. ,vol. 61, pp. 50- 59 ,(1987) , 10.1128/JVI.61.1.50-59.1987
Felipe L Saback, Selma A Gomes, Christian Niel, High frequency of mixed TT virus infections in healthy adults and children detected by a simplified heteroduplex mobility assay. Journal of Virological Methods. ,vol. 101, pp. 117- 125 ,(2002) , 10.1016/S0166-0934(01)00425-6
Z HUSSAIN, B DAS, S HUSAIN, M ASIM, S CHATTOPADHYAY, A MALIK, Y POOVORAWAN, A THEAMBOONLERS, P KAR, Hepatitis A viral genotypes and clinical relevance: Clinical and molecular characterization of hepatitis A virus isolates from northern India Hepatology Research. ,vol. 32, pp. 16- 24 ,(2005) , 10.1016/J.HEPRES.2005.01.014
G. Dunn, V. Patel, A. Phillips, N. Cammack, P.D. Minor, Intertypic genomic rearrangements of poliovirus strains in vaccinees. Virology. ,vol. 167, pp. 507- 514 ,(1988) , 10.1016/0042-6822(88)90113-4
Aniko V. Paul, Hiroomi Tada, Klaus von der Helm, T. Wissel, R. Kiehn, Eckard Wimmer, Friedrich Deinhardt, The entire nucleotide sequence of the genome of human hepatitis A virus (isolate MBB). Virus Research. ,vol. 8, pp. 153- 171 ,(1987) , 10.1016/0168-1702(87)90026-8
J. I. Cohen, B. Rosenblum, J. R. Ticehurst, R. J. Daemer, S. M. Feinstone, R. H. Purcell, Complete nucleotide sequence of an attenuated hepatitis A virus: comparison with wild-type virus. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 2497- 2501 ,(1987) , 10.1073/PNAS.84.8.2497
Keiichi Fujiwara, Osamu Yokosuka, Kenichi Fukai, Fumio Imazeki, Hiromitsu Saisho, Masao Omata, Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis Journal of Hepatology. ,vol. 35, pp. 112- 119 ,(2001) , 10.1016/S0168-8278(01)00074-5