Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study
作者： Aleksandar J. Ristić , Jelena Ostojić , Duško Kozić , Nikola M. Vojvodić , Ljubica M. Popović
DOI: 10.1016/J.JNS.2010.12.022
关键词: Creatine 、 Juvenile myoclonic epilepsy 、 Metabolic disorder 、 Hippocampal formation 、 Choline 、 Endocrinology 、 Hippocampus (mythology) 、 Internal medicine 、 Myoclonic epilepsy 、 Medicine 、 Epilepsy
摘要: Abstract Purpose To investigate the metabolic differences in hippocampi of patients with juvenile myoclonic epilepsy (JME) and healthy controls using magnetic resonance spectroscopy (MRS). Methods A 3D multivoxel SE 135 MRS study on 1.5 T scanner both was performed 17 JME normal brain MRI 19 age sex matched controls. Three dominant signals were measured: Choline (Cho), Creatine (tCr) N-Acetylaspartate (NAA) expressed as ratios Cho:tCr, NAA:tCr, NAA:Cho NAA:(Cho + tCr). Metabolite head, body tail each hippocampus group compared from corresponding structures control group. Results We found a significant difference metabolite between groups. detected Cho:tCr NAA:tCr tail, NAA:(Cho + tCr) left hippocampus, right hippocampus. Discussion Although not previously recognized part epileptogenic network, our results suggest that well key player focal epilepsies , may have certain role pathogenesis JME.
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Jonathan Mark Dickson, Iain David Wilkinson, Stephen John Lamb Howell, Paul David Griffiths, Richard Adam Grünewald, Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy. Journal of Neurology, Neurosurgery, and Psychiatry. ,vol. 77, pp. 834- 840 ,(2006) , 10.1136/JNNP.2005.086918
A. V. Delgado-Escueta, F. Enrile-Bacsal, Juvenile myoclonic epilepsy of Janz Neurology. ,vol. 34, pp. 285- 285 ,(1984) , 10.1212/WNL.34.3.285
Kevin G. King, Lidia Glodzik, Songtao Liu, James S. Babb, Mony J. de Leon, Oded Gonen, Anteroposterior hippocampal metabolic heterogeneity: three-dimensional multivoxel proton 1H MR spectroscopic imaging--initial findings. Radiology. ,vol. 249, pp. 242- 250 ,(2008) , 10.1148/RADIOL.2491071500
Susanne G. Mueller, Kenneth D. Laxer, Jerome A. Barakos, Nathan Cashdollar, Derek L. Flenniken, Peter Vermathen, Gerald B. Matson, Michael W. Weiner, Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging. Epilepsia. ,vol. 45, pp. 1580- 1589 ,(2004) , 10.1111/J.0013-9580.2004.53003.X
Rhandi Senaratne, Andrea M. Milne, Glenda M. MacQueen, Geoffrey B.C. Hall, Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study. Psychiatry Research-neuroimaging. ,vol. 172, pp. 205- 209 ,(2009) , 10.1016/J.PSCYCHRESNS.2008.07.007
Robert J. Simister, Mary A. McLean, Gareth J. Barker, John S. Duncan, The effect of sodium valproate on proton MRS visible neurochemical concentrations. Epilepsy Research. ,vol. 74, pp. 215- 219 ,(2007) , 10.1016/J.EPLEPSYRES.2007.03.001
Mark D. Holmes, Jason Quiring, Don M. Tucker, Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks. NeuroImage. ,vol. 49, pp. 80- 93 ,(2010) , 10.1016/J.NEUROIMAGE.2009.08.004
Woo Suk Tae, Eun Yeon Joo, Sun Jung Han, Kyung-Han Lee, Seung Bong Hong, CBF changes in drug naive juvenile myoclonic epilepsy patients Journal of Neurology. ,vol. 254, pp. 1073- 1080 ,(2007) , 10.1007/S00415-006-0491-6
Hans O. Lüders, John Turnbull, Farhad Kaffashi, Are the dichotomies generalized versus focal epilepsies and idiopathic versus symptomatic epilepsies still valid in modern epileptology Epilepsia. ,vol. 50, pp. 1336- 1343 ,(2009) , 10.1111/J.1528-1167.2009.02074.X
W. S. Tae, S. H. Kim, E. Y. Joo, S. J. Han, I. Y. Kim, S. I. Kim, J.-M. Lee, S. B. Hong, Cortical thickness abnormality in juvenile myoclonic epilepsy Journal of Neurology. ,vol. 255, pp. 561- 566 ,(2008) , 10.1007/S00415-008-0745-6