Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy.
作者： Jonathan Mark Dickson , Iain David Wilkinson , Stephen John Lamb Howell , Paul David Griffiths , Richard Adam Grünewald
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摘要: Background: The memory deficits in patients with temporal lobe epilepsy (TLE) are associated epileptogenic lesions of the lobes, especially hippocampal sclerosis. Memory have been extensively studied TLE, but presence pre-existing abnormality has confounded studies on relationship between dysfunction and seizure activity. Idiopathic generalised (IGE) is characterised by primary seizures found to occur absence any macroscopic brain abnormalities. IGE therefore ideal for investigations effects activity cognition. Aim methods: Magnetic resonance spectroscopy (MRS) neuropsychological testing were used investigate epileptic seizures, performance neuronal lobes a group IGE. 30 15 healthy controls participated study. Results: Patients perform worse than tests speed information processing, general cognitive range tests, including face recognition, word verbal recall complex figure recall. patient visual recognition sections Doors People Test was correlate MRS ratios N-acetyl aspartate:choline aspartate:creatine lobes. Conclusion: This result supports hypothesis that may be due secondary itself
sci-hub.se 参考文章(27)
Albert P. Aldenkamp, Marc De Krom, Rianne Reijs, Newer antiepileptic drugs and cognitive issues. Epilepsia. ,vol. 44, pp. 21- 29 ,(2003) , 10.1046/J.1528-1157.44.S4.3.X
A. Connelly, W. Van Paesschen, D. A. Porter, C. L. Johnson, J. S. Duncan, D. G. Gadian, Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy Neurology. ,vol. 51, pp. 61- 66 ,(1998) , 10.1212/WNL.51.1.61
Gholam K. Motamedi, Kimford J. Meador, Antiepileptic drugs and memory Epilepsy & Behavior. ,vol. 5, pp. 435- 439 ,(2004) , 10.1016/J.YEBEH.2004.03.006
Howard Eichenbaum, The hippocampus and mechanisms of declarative memory Behavioural Brain Research. ,vol. 103, pp. 123- 133 ,(1999) , 10.1016/S0166-4328(99)00044-3
Caroline Dautry, Françoise Vaufrey, Emmanuel Brouillet, Nicolas Bizat, Pierre-Gilles Henry, Françoise Condé, Gilles Bloch, Philippe Hantraye, Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid. Journal of Cerebral Blood Flow and Metabolism. ,vol. 20, pp. 789- 799 ,(2000) , 10.1097/00004647-200005000-00005
Harry Meinardi, A Tribute to K. S. Mani, 1928–2001 Epilepsia. ,vol. 44, pp. 2- 4 ,(2003) , 10.1046/J.1528-1157.44.S.1.7.X
Jutta Urenjak, Stephen R. Williams, David G. Gadian, Mark Noble, Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. Journal of Neurochemistry. ,vol. 59, pp. 55- 61 ,(1992) , 10.1111/J.1471-4159.1992.TB08875.X
I. J. Namer, N. R. Bolo, F. Sellal, V. H. Nguyen, J. F. Nedelec, E. Hirsch, C. Marescaux, Combined measurements of hippocampal N-acetyl-aspartate and T2 relaxation time in the evaluation of mesial temporal lobe epilepsy: correlation with clinical severity and memory performances. Epilepsia. ,vol. 40, pp. 1424- 1432 ,(1999) , 10.1111/J.1528-1157.1999.TB02015.X
T. V Perneger, What's wrong with Bonferroni adjustments BMJ. ,vol. 316, pp. 1236- 1238 ,(1998) , 10.1136/BMJ.316.7139.1236
Véronique Lespinet, Christel Bresson, Bernard N’Kaoua, Alain Rougier, Bernard Claverie, Effect of age of onset of temporal lobe epilepsy on the severity and the nature of preoperative memory deficits. Neuropsychologia. ,vol. 40, pp. 1591- 1600 ,(2002) , 10.1016/S0028-3932(02)00012-X