Highly tumor-reactive, internalizing, mouse monoclonal antibodies to Le(y)-related cell surface antigens.

摘要: Two monoclonal antibodies, designated BR64 (IgG1) and BR96 (IgG3), were generated that, according to immunohistology, bind selectively carcinomas of the colon, breast, ovary, lung. They have no or very low reactivity with normal human tissues, except for fact that stains capillaries in hearts from certain donors both antibodies stain some epithelial cells gastrointestinal system, including stomach. Preliminary studies indicate at least a portion epitope recognized by is Ley carbohydrate chain. Both can be “ipternalized” antigen-positive tumor cells, since immunoconjugates ricin A-chain are cytotoxic. has additional properties being cytotoxic itself, it mediate antibody-dependent cellular cytotoxicity complement dependent cytotoxicity.