Fractional allelic loss in non–end‐stage cirrhosis: Correlations with hepatocellular carcinoma development during follow‐up
作者： Massimo Roncalli , Paolo Bianchi , Giorgia Ceva Grimaldi , Daniele Ricci , Luigi Laghi
DOI: 10.1053/HE.2000.5790
关键词: Microsatellite instability 、 Stage (cooking) 、 Biology 、 Allele 、 Complication 、 Hepatocellular carcinoma 、 Internal medicine 、 Basal (phylogenetics) 、 Gastroenterology 、 Cirrhosis 、 Pathology 、 Chronic liver disease
摘要: Hepatocellular carcinoma (HCC) is usually preceded by cirrhosis whose genetic background still poorly understood. The aim of this study was to evaluate, in non–end-stage cirrhosis, the fractional allelic loss (FAL) at loci mostly reported be altered HCC and microsatellite instability (MSI). Twenty cases were retrospectively selected. Eleven had developed an during follow-up (HCC-prone group), while 9 remained HCC-free (HCC-free group). Microdissected hepatocellular cirrhotic nodules from basal liver biopsies, studied 20 (on chromosomal arms 1p 1q, 3p, 4q, 6q, 7q, 8p, 13q, 18q) with mononucleotide repeats BAT26andTGFbIIR. Genetic changes detected both groups. Overall, FAL index statistically increased HCC-prone group (0.213) as compared (0.094; P = .044). Allelic 1p, 18q, concurrent losses more than 3 confined group. In groups, MSI never ascertained using BAT26and TGFbIIR. conclusion, lack characterize patients undergoing follow-up. These data emphasize role early clonal chronic disease, their potential predictive significance for clinical use.
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