Deletion mapping of chromosome 16q in hepatocellular carcinoma
作者： Z Piao , C Park , J J Kim , H Kim
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摘要: Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed at one or more loci. Among 35 with AI, 21 multiple suggesting wide scope deletion long arm 16, and remaining 14 partial AI. Detailed mapping identified two independent deleted this arm. These included D16S3106 locus D16S498 locus. conclusion, have demonstrated frequent 16q loci which may harbour new tumour suppressor genes.
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ADRIAN M. DI BISCEGLIE, Hepatocellular Carcinoma Annals of Internal Medicine. ,vol. 108, pp. 390- 401 ,(1988) , 10.7326/0003-4819-108-3-390
Isaburo Fujimoto, Yoshinori Urano, Aya Hanai, Kunio Okuda, Changing incidence of hepatocellular carcinoma in Japan. Cancer Research. ,vol. 47, pp. 4967- 4972 ,(1987)
Perry E. Telzerow, Andrew P. Feinberg, Michael R. Eccles, Paul E. Grundy, Marion A. Maw, Roseanne S. Dunn, Robert I. Richards, Malcolm C. Paterson, Lynn J. Millow, Anthony E. Reeve, Andrew D. Thompson, David F. Callen, Dave J. Law, Peter J. Smith, A Third Wilms' Tumor Locus on Chromosome 16q Cancer Research. ,vol. 52, pp. 3094- 3098 ,(1992)
Taiping Chen, Aysegul Sahin, C. Marcelo Aldaz, Deletion Map of Chromosome 16q in Ductal Carcinoma in Situ of the Breast: Refining a Putative Tumor Suppressor Gene Region Cancer Research. ,vol. 56, pp. 5605- 5609 ,(1996)
Magnus Nordenskjöld, Annika Lindblom, Catharina Larsson, Lambert Skoog, Sam Rotstein, Deletions on Chromosome 16 in Primary Familial Breast Carcinomas Are Associated with Development of Distant Metastases Cancer Research. ,vol. 53, pp. 3707- 3711 ,(1993)
Colette Dib, Sabine Fauré, Cécile Fizames, Delphine Samson, Nathalie Drouot, Alain Vignal, Philippe Millasseau, Sophie Marc, Jamile Kazan, Eric Seboun, Mark Lathrop, Gabor Gyapay, Jean Morissette, Jean Weissenbach, A comprehensive genetic map of the human genome based on 5,264 microsatellites Nature. ,vol. 380, pp. 152- 154 ,(1996) , 10.1038/380152A0
B. S. Carter, C. M. Ewing, W. S. Ward, B. F. Treiger, T. W. Aalders, J. A. Schalken, J. I. Epstein, W. B. Isaacs, Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 8751- 8755 ,(1990) , 10.1073/PNAS.87.22.8751
NA Gruis, ECA Abeln, AFJ Bardoel, P Devilee, RR Frants, CJ Cornelisse, PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumour tissue. British Journal of Cancer. ,vol. 68, pp. 308- 313 ,(1993) , 10.1038/BJC.1993.333
SH Yeh, PJ Chen, MY Lai, DS Chen, Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: Association with elevated alpha-fetoprotein production Gastroenterology. ,vol. 110, pp. 184- 192 ,(1996) , 10.1053/GAST.1996.V110.PM8536855
Naoshi Nishida, Yoshihoro Fukuda, Hiroyuki Kokuryu, Tetuo Sadamoto, Gohei Isowa, Kazuo Honda, Yoshio Yamaoka, Mituo Ikenaga, Hiroo Imura, Kanji Ishizaki, Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma. International Journal of Cancer. ,vol. 51, pp. 862- 868 ,(1992) , 10.1002/IJC.2910510605