Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats
作者： Andrew M Seacat , Peter J Thomford , Kris J Hansen , Lisa A Clemen , Sandra R Eldridge
DOI: 10.1016/S0300-483X(02)00511-5
关键词: Dose–response relationship 、 Internal medicine 、 Cumulative dose 、 Oral administration 、 Cholesterol 、 No-observed-adverse-effect level 、 Toxicity 、 Proliferation index 、 Hepatocyte 、 Endocrinology 、 Chemistry
摘要: Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans fish-eating wildlife. This study investigated the hypotheses that early hepatocellular peroxisomal proliferation hepatic cellular are factors chronic response to dietary dosing, lowering of total cholesterol an clinical measure treatment, PFOS proportional dose cumulative after sub-chronic treatment. was administered diet as potassium salt 0, 0.5, 2.0, 5.0, 20 parts per million (ppm) Sprague Dawley rats for 4 or 14 weeks. At weeks, effects included decreased glucose equivocal (
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