Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb‐unloaded rats by astaxanthin supplementation and intermittent loading

摘要: A chronic decrease in neuromuscular activity (activation and/or loading) results muscle atrophy and capillary regression that are due, part, to the overproduction of reactive oxygen species. We have reported antioxidant treatment with astaxanthin attenuates overexpression species atrophied muscles that, turn, ameliorates hindlimb-unloaded rats. Astaxanthin supplementation, however, had little effect on mass fibre cross-sectional area. In contrast, intermittent loading hindlimbs rats atrophy. Therefore, we hypothesized combination supplementation would attenuate both during hindlimb unloading. As expected, 2 weeks unloading resulted atrophy, a volume shift towards smaller-diameter capillaries soleus muscle. Intermittent alone (1 h cage ambulation per day) attenuated soleus, while maintained network near control levels. The treatment, ameliorated luminal diameters superoxide dismutase-1 protein levels values. These indicate combined could be an effective therapy for associated activity.