Preventive effects of nucleoprotein supplementation combined with intermittent loading on capillary regression induced by hindlimb unloading in rat soleus muscle.
作者： Yusuke Hirayama , Ryosuke Nakanishi , Noriaki Maeshige , Hidemi Fujino
DOI: 10.14814/PHY2.13134
关键词:
摘要: Abstract Physical inactivity leads to muscle atrophy and capillary regression in the skeletal muscle. Intermittent loading during hindlimb unloading attenuates atrophy, meanwhile is not suppressed. Nucleoprotein has antioxidant capacity may prevent regression. Therefore, we assessed combined effects of intermittent with nucleoprotein supplementation on induced by unloading. Five groups rats were assigned: control (CON), 7 days (HU), HU plus (HU + NP), (HU + IL), (HU + IL + NP). Seven days resulted decrease number‐to‐fiber number (C/F) ratio accompanied disuse‐associated changes fetal liver kinase‐1 (Flk‐1), a proangiogenesis factor, thrombospondin‐1 (TSP‐1), an antiangiogenesis soleus In addition, citrate synthase (CS) activity was decreased protein level superoxide dismutase (SOD)‐2 increased. Neither nor prevented C/F ratio, whereas Moreover, levels Flk‐1, TSP‐1, SOD‐2 CS maintained up levels. These results suggested that effective atrophy.
sci-hub.se 参考文章(34)
Craig S. Stump, Charles M. Tipton, Erik J. Henriksen, Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats Journal of Applied Physiology. ,vol. 82, pp. 1875- 1881 ,(1997) , 10.1152/JAPPL.1997.82.6.1875
Masayuki Tanaka, Miho Kanazashi, Toshiyuki Maezawa, Hiroyo Kondo, Hidemi Fujino, Abnormalities in three-dimensional capillary architecture and imbalance between vascular endothelial growth factor-A and thrombospondin-1 in soleus muscle of ovariectomized rat Acta Histochemica. ,vol. 117, pp. 605- 611 ,(2015) , 10.1016/J.ACTHIS.2015.06.001
I. MARK OLFERT, OLIVIER BIROT, Importance of anti-angiogenic factors in the regulation of skeletal muscle angiogenesis. Microcirculation. ,vol. 18, pp. 316- 330 ,(2011) , 10.1111/J.1549-8719.2011.00092.X
Miho Kanazashi, Masayuki Tanaka, Shinichiro Murakami, Hiroyo Kondo, Fumiko Nagatomo, Akihiko Ishihara, Roland R. Roy, Hidemi Fujino, Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb‐unloaded rats by astaxanthin supplementation and intermittent loading Experimental Physiology. ,vol. 99, pp. 1065- 1077 ,(2014) , 10.1113/EXPPHYSIOL.2014.079988
Emilie Roudier, Charlotte Gineste, Alexandra Wazna, Kooroush Dehghan, Dominique Desplanches, Olivier Birot, Angio-adaptation in unloaded skeletal muscle: new insights into an early and muscle type-specific dynamic process. The Journal of Physiology. ,vol. 588, pp. 4579- 4591 ,(2010) , 10.1113/JPHYSIOL.2010.193243
D J Baylink, E R Morey, R T Turner, E E Sabelman, A new rat model simulating some aspects of space flight. The Physiologist. ,vol. 22, ,(1979)
Andréia Machado Cardoso, Caroline Curry Martins, Fernando da Silva Fiorin, Roberta Schmatz, Fátima Husein Abdalla, Jessié Gutierres, Daniela Zanini, Amanda Maino Fiorenza, Naiara Stefanello, Jonas Daci da Silva Serres, Fabiano Carvalho, Verônica Paiva Castro, Cinthia Melazzo Mazzanti, Luiz Fernando Freire Royes, Adriane Belló-Klein, Jeferson Ferraz Goularte, Vera Maria Morsch, Margarete Dulce Bagatini, Maria Rosa Chitolina Schetinger, Physical training prevents oxidative stress in L-NAME-induced hypertension rats. Cell Biochemistry and Function. ,vol. 31, pp. 136- 151 ,(2013) , 10.1002/CBF.2868
Maurizio Vitadello, Elena Germinario, Barbara Ravara, Luciano Dalla Libera, Daniela Danieli-Betto, Luisa Gorza, Curcumin counteracts loss of force and atrophy of hindlimb unloaded rat soleus by hampering neuronal nitric oxide synthase untethering from sarcolemma. The Journal of Physiology. ,vol. 592, pp. 2637- 2652 ,(2014) , 10.1113/JPHYSIOL.2013.268672
Pierluigi Cassano, Martin Flück, Anna Giovanna Sciancalepore, Vito Pesce, Menotti Calvani, Hans Hoppeler, Palmiro Cantatore, Maria Nicola Gadaleta, Muscle unloading potentiates the effects of acetyl‐L‐carnitine on the slow oxidative muscle phenotype Biofactors. ,vol. 36, pp. 70- 77 ,(2010) , 10.1002/BIOF.74
Esther E. Dupont-Versteegden, Micheal Knox, Cathy M. Gurley, John D. Houlé, Charlotte A. Peterson, Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway American Journal of Physiology-cell Physiology. ,vol. 282, ,(2002) , 10.1152/AJPCELL.00424.2001