Activation of interleukin- 1β by a co-induced protease
作者： Roy A. Black , Shirley R. Kronheim , Paul R. Sleath
DOI: 10.1016/0014-5793(89)81376-6
关键词: Proteases 、 Biosynthesis 、 Cytoplasm 、 Proteolytic enzymes 、 Iodoacetic acid 、 Interleukin 、 Biochemistry 、 Enzyme 、 Protease 、 Biology 、 Biophysics 、 Genetics 、 Cell biology 、 Molecular biology 、 Structural biology
摘要: The proteolytic generation of mature interleukin-1β (IL-1β) from its inactive precursor does not proceed by a conventional pathway for hormonal processing. Pro-IL-1β is found dispersed in the cytoplasm, and there are no basic amino acid residues or other commonly recognized processing sites adjoining the mature N-terminus. Processing appears to occur during release of the hormone. In the present study, we have identified a specific protease that generates mature IL-1β from the precursor. This enzyme is co-induced with the …
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