Biology Without Walls: The Novel Endocrinology of Bone
作者： Gerard Karsenty , Franck Oury
DOI: 10.1146/ANNUREV-PHYSIOL-020911-153233
关键词: Hormone 、 Biology 、 Endocrinology 、 Bone remodeling 、 Energy metabolism 、 Vertebrate 、 Bone physiology 、 Leptin 、 Internal medicine 、 Cell type 、 Endocrine system
摘要: Classical studies of vertebrate physiology have usually been confined to a given organ or cell type. The use mouse genetics has changed this approach and rejuvenated the concept whole-body study physiology. One physiological system that profoundly influenced by is skeletal Indeed, genetic approaches identified several unexpected organs affect bone These new links begun provide plausible explanation for evolutionary involvement hormones such as leptin with also revealed true endocrine capable regulating energy metabolism reproduction. Collectively, body work discussed below illustrates unconventional role in mammalian
sci-hub.se 参考文章(113)
Peter Kristensen, Martin E. Judge, Lars Thim, Ulla Ribel, Kennet N. Christjansen, Birgitte S. Wulff, Jes T. Clausen, Per B. Jensen, Ole D. Madsen, Niels Vrang, Philip J. Larsen, Sven Hastrup, Hypothalamic CART is a new anorectic peptide regulated by leptin Nature. ,vol. 393, pp. 72- 76 ,(1998) , 10.1038/29993
Walter Bradford Cannon, The wisdom of the body ,(1932)
Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. Journal of Biological Chemistry. ,vol. 269, pp. 30659- 30667 ,(1994) , 10.1016/S0021-9258(18)43864-1
Veronique Pelloux, Dominique Cassuto, Micheline Gourmelen, Christian Dina, Jean Chambaz, Jean-Marc Lacorte, Arnaud Basdevant, Pierre Bougnères, Yves Lebouc, Philippe Froguel, Bernard Guy-Grand, Karine Clément, Christian Vaisse, Najiba Lahlou, Sylvie Cabrol, A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction Nature. ,vol. 392, pp. 398- 401 ,(1998) , 10.1038/32911
Albert F. Debons, Lawrence Silver, Eugene P. Cronkite, Horton A. Johnson, George Brecher, Doris Tenzer, Irving L. Schwartz, Localization of gold in mouse brain in relation to gold thioglucose obesity American Journal of Physiology-Legacy Content. ,vol. 202, pp. 743- 750 ,(1962) , 10.1152/AJPLEGACY.1962.202.4.743
I.R Reid, Relationships among body mass, its components, and bone. Bone. ,vol. 31, pp. 547- 555 ,(2002) , 10.1016/S8756-3282(02)00864-5
Patricia Ducy, Michael Amling, Shu Takeda, Matthias Priemel, Arndt F Schilling, Frank T Beil, Jianhe Shen, Charles Vinson, Johannes M Rueger, Gerard Karsenty, Leptin Inhibits Bone Formation through a Hypothalamic Relay: A Central Control of Bone Mass Cell. ,vol. 100, pp. 197- 207 ,(2000) , 10.1016/S0092-8674(00)81558-5
Michael D. Gershon, Jan Tack, The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders Gastroenterology. ,vol. 132, pp. 397- 414 ,(2007) , 10.1053/J.GASTRO.2006.11.002
Xiangli Yang, Koichi Matsuda, Peter Bialek, Sylvie Jacquot, Howard C Masuoka, Thorsten Schinke, Lingzhen Li, Stefano Brancorsini, Paolo Sassone-Corsi, Tim M Townes, Andre Hanauer, Gerard Karsenty, ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology: Implication for Coffin-Lowry Syndrome Cell. ,vol. 117, pp. 387- 398 ,(2004) , 10.1016/S0092-8674(04)00344-7
Mathieu Ferron, Jianwen Wei, Tatsuya Yoshizawa, Andrea Del Fattore, Ronald A. DePinho, Anna Teti, Patricia Ducy, Gerard Karsenty, Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism Cell. ,vol. 142, pp. 296- 308 ,(2010) , 10.1016/J.CELL.2010.06.003