Cyclosporine-induced apoptosis in CD4+ T lymphocytes and computer-simulated analysis: modeling a treatment scenario for HIV infection

摘要: Summary Cyclosporine A (CsA) is a potent immunosuppressive drug which interferes in vitro and vivo with T-cell function. CsA has been shown to arrest maturation intra-thymically inhibit proliferation. In this study, we demonstrate that induces apoptosis the canine CD4 + CD8 − T-lymphocyte cell line 401 dose- time-dependent fashion. Similar results could also be obtained from human peripheral blood lymphocytes. Apoptosis observed within 4 hours after application not prevented by excessive addition of ConA supernatant as source interleukins. The induction T lymphocytes suggests possible treatment option for immunodeficiency virus (HIV) infections, since major target population HIV would ablated at short term. computer-simulated analysis “Cybermouse” model confirmed eventually disappear HIV-infected macrophages substantially reduced if were given combination drugs block viral replication (3′-azido 3′-deoxythymidine or 2′,3′-dideoxycytidine). This scenario applied under controlled conditions supportive patient care. further review literature positive impact on progression outcome AIDS-related mortality.