Role of glucose and insulin in the dynamic regulation of glucagon release by the perfused rat pancreas

作者: V. Leclercq-Meyer , J. Marchand , W.J. Malaisse

DOI: 10.1007/BF00250160

关键词: Glucagon secretionBlood sugar regulationStimulationIn vitroInternal medicineGlucagonCellInsulinChemistryInsulin oscillationEndocrinology

摘要: The effect of glucose upon the release glucagon and insulin from perfused rat pancreas in vitro was studied by varying both concentration (from 3.3 to 4.6, 8.5, or 11.1 mmol/l) time exposure an elevated sugar (5, 10 23 min). results suggest that amount released during early period stimulation could contribute speed extent inhibition release. rate recovery A cell, however, appeared be independent related, a dose-dependent time-dependent manner, only stimulus. It is suggested direct cell involved physiological regulation secretion. An indirect glucose, as mediated via release, may rapidity magnitude secretory activity.

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