A Genetic Explanation of Slaughter’s Concept of Field Cancerization: Evidence and Clinical Implications

作者: Ruud H Brakenhoff , Boudewijn J M Braakhuis , Maarten P Tabor , C René Leemans , J Alain Kummer

DOI:

关键词: Primary tumorEsophagusCancerBiologyPathologyField cancerizationBreast cancerStem cellCarcinogenesisCarcinoma

摘要: … Several lines of evidence, presented by us and other investigators, indicate that the presence of a field lesion with genetically altered cells is a distinct biological stage in epithelial …

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