Role of genetic polymorphisms in hepatitis C virus chronic infection.
作者： Nicola Coppola , Mariantonietta Pisaturo , Caterina Sagnelli , Lorenzo Onorato , Evangelista Sagnelli
关键词: Hepatitis C 、 Single-nucleotide polymorphism 、 Anemia 、 Interleukin 28B 、 Chronic infection 、 Bioinformatics 、 Medicine 、 Hepatitis C virus 、 Steatosis 、 Immunology 、 Pegylated interferon
摘要: AIM: To analyze the host genetics factors influencing clinical course and response to antiviral treatment in patients with chronic hepatitis C (CHC). METHODS: We conducted an electronic search on PubMed MEDLINE (2000-2014) databases Cochrane library (2000-2014). A total of 73 articles were retrieved their data extensively evaluated discussed by authors then analyzed this review article. RESULTS: Several studies associated polymorphisms interleukin 28B gene chromosome 19 (19q13.13) a spontaneous viral clearance acute pegylated interferon (Peg-IFN)-based patients. Other investigations demonstrated that inosine triphosphate pyrophosphatase genetic variants protect virus-genotype-1 CHC from ribavirin-induced anemia, other polymorphism patatin-like phospholipase domain-containing protein 3 was hepatic steatosis Although not conclusive, some suggested vitamin D-associated play important role achievement sustained virologic treated Peg-IFN-based therapy. have been investigated ascertain possible impact natural history CHC, but are preliminary warrant confirmation. CONCLUSION: seem influence suggesting individualized follow up strategies.
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