Cerebral amyloid-β accumulation and deposition following traumatic brain injury--A narrative review and meta-analysis of animal studies

摘要: Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying relationship between TBI and diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link increased amyloid-β (Aβ), protein involved in AD pathogenesis. Here, we review animal that measured Aβ levels following TBI. In addition, from pool initially identified 1209 published papers, examined data 19 eligible model using meta-analytic approach. We found an acute increase cerebral ranging 24h one month (overall log OR=2.97 ± 0.40, p<0.001). These findings may contribute further understanding future dementia risk. The methodological inconsistencies discussed this suggest need for improved more standardised collection study design, order properly elucidate role expression accumulation Aβ.