Sphingosine-1-phosphate receptor agonists in the treatment of demyelinating disorders

作者: Paul William Glue , Peter C. Hiestand , Carolyn Ann Foster

DOI:

关键词: PharmacologyImmunologySphingosine-1-phosphate receptorDemyelinating diseaseDemyelinating DisorderAgonistMedicineMultiple sclerosisSequence (medicine)

摘要: Disclosed are pharmaceutical combinations comprising at least one S1P receptor agonist, as well a method for treating demyelinating diseases, e.g. multiple sclerosis or disorders associated therewith Guillain-Barre syndrome, co-administration, concomitantly in sequence, of therapeutically effective amount a) an and b) co-agent shown to have clinical activity against symptom disease.

参考文章(12)
Masatoshi Kiuchi, Kenji Chiba, Tadashi Mishina, Koji Teshima, Toshiyuki Kohara, Kunitomo Adachi, Tetsuro Fujita, Benzene compound and pharmaceutical use thereof ,(1997)
Hugo W. Moser, Clinical and therapeutic aspects of adrenoleukodystrophy and adrenomyeloneuropathy Journal of Neuropathology and Experimental Neurology. ,vol. 54, pp. 740- 745 ,(1995) , 10.1097/00005072-199509000-00017
Volker Brinkmann, Kevin R Lynch, FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity Current Opinion in Immunology. ,vol. 14, pp. 569- 575 ,(2002) , 10.1016/S0952-7915(02)00374-6
Y Hoshino, Y Yanagawa, M Ohtsuki, S Nakayama, T Hashimoto, K Chiba, FTY720, a novel immunosuppressant, shows a synergistic effect in combination with FK 506 in rat allograft models. World Congress of the Transplantation Society. ,vol. 31, pp. 1224- 1226 ,(1999) , 10.1016/S0041-1345(98)01973-3
John H. Musser, Philip F. Hughes, Rapamycin analog as immunosuppressants and antifungals ,(1992)
Yoshiyuki Aoki, Koji Teshima, Yukio Hoshino, Kunitomo Adachi, Tokushi Hanano, Tetsuro Fujita, 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same ,(1998)
Volker Brinkmann, Michael D. Davis, Christopher E. Heise, Rainer Albert, Sylvain Cottens, Robert Hof, Christian Bruns, Eva Prieschl, Thomas Baumruker, Peter Hiestand, Carolyn A. Foster, Markus Zollinger, Kevin R. Lynch, The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Journal of Biological Chemistry. ,vol. 277, pp. 21453- 21457 ,(2002) , 10.1074/JBC.C200176200
William H. Parsons, Malcolm Maccoss, Kathleen Rupprecht, James Bergstrom, Hugh Rosen, Deborah J. Card, Suzanne Mandala, Richard Hajdu, Phosphate derivatives as immunoregulatory agents ,(2001)
Hermann Graf, Daryl Faulds, Daniel Perez, Helmut Wachtel, Harald Dinter, Synergistic treatment of multiple sclerosis and other neurodegenerative disorders ,(1997)