Macrophage migration inhibitory factor (MIF) gene is associated with adolescents' cortisol reactivity and anxiety.

摘要: Abstract Emerging evidence points to interactions between inflammatory markers and stress reactivity in predicting mental health risk, but underlying mechanisms are not well understood. Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine involved signaling Hypothalamus Pituitary Adrenal (HPA) axis stress-response, has recently been identified as candidate biomarker for depression anxiety risk. We examined polymorphic variations of the MIF gene association with baseline levels, HPA reactivity, self-reported responses social stressor 74 adolescents, ages 10–14 years. Genotyping was performed two polymorphisms, -794 CATT5-8 tetranucleotide repeat -173*G/C single nucleotide polymorphism (SNP). Youth carrying MIF-173*C CATT7 alleles displayed attenuated cortisol when compared non-carriers. Children CATT7-173*C haplotype lower those without this haplotype. Additionally, CATT5-173*C CATT6-173*C haplotypes were associated ratings across stressor. Results extend prior work pointing influence on neuroendocrine response suggest potential pathophysiological pathway risk stress-related physical disorders. To our knowledge, these first data showing associations gene, symptoms during adolescence.