Preliminary associations between childhood neglect, MIF, and cortisol: potential pathways to long-term disease risk.
作者： Johanna Bick , Victoria Nguyen , Lin Leng , Marta Piecychna , Michael J. Crowley
DOI: 10.1002/DEV.21265
关键词:
摘要: The study examined Hypothalamus Pituitary Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure self reported maltreatment. Youth severe neglect showed elevated levels cortisol, the end product HPA axis, comparison to lower or minimal neglect. Histories also were associated increased Macrophage Migration Inhibitory Factor (MIF), a cytokine known be intricately involved regulation. Salivary MIF positively age exposure. These cortisol alterations may signal pathophysiological disruptions neuro endocrine immune systems, which lead trajectories disease risk among vulnerable youth. Our findings provide preliminary support for validity reliability noninvasive salivary assessment MIF.
sci-hub.se 参考文章(52)
A. Meinhardt, R. Bucala, W. Mu, H. Y. Lan, T. Donnelly, C. N. Metz, R. C. Atkins, T. Calandra, M. Bacher, J. A. Chesney, D. Gemsa, Migration inhibitory factor expression in experimentally induced endotoxemia. American Journal of Pathology. ,vol. 150, pp. 235- 246 ,(1997)
Rickard L. Sjöberg, Long-term Neuroendocrine Effects of Childhood Maltreatment JAMA. ,vol. 284, pp. 2321- 2321 ,(2000) , 10.1001/JAMA.284.18.2317
Tampanaru-Sarmesiu A, Donnelly T, Metz Cn, Kovacs K, Bucala R, Stefaneanu L, Thapar K, Immunocytochemical localization of macrophage migration inhibitory factor in human hypophysis and pituitary adenomas. Archives of Pathology & Laboratory Medicine. ,vol. 121, pp. 404- 410 ,(1997)
T. Calandra, R. Bucala, Macrophage migration inhibitory factor: a counter-regulator of glucocorticoid action and critical mediator of septic shock. Journal of Inflammation. ,vol. 47, pp. 39- 51 ,(1995)
Toshihiko Nishino, Jürgen Bernhagen, Hideo Shiiki, Thierry Calandra, Kazuhiro Dohi, Richard Bucala, Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland Molecular Medicine. ,vol. 1, pp. 781- 788 ,(1995) , 10.1007/BF03401892
Initial reliability and validity of a new retrospective measure of child abuse and neglect. American Journal of Psychiatry. ,vol. 151, pp. 1132- 1136 ,(1994) , 10.1176/AJP.151.8.1132
Sakurako Katsuura, Yoshiko Kamezaki, Kumiko Tominaga, Kiyoshi Masuda, Kensei Nishida, Yuta Yamamoto, Keiko Takeo, Naoko Yamagishi, Toshihito Tanahashi, Tomoko Kawai, High-throughput screening of brief naturalistic stress-responsive cytokines in university students taking examinations International Journal of Psychophysiology. ,vol. 77, pp. 135- 140 ,(2010) , 10.1016/J.IJPSYCHO.2010.05.004
Linda L. Carpenter, John P. Carvalho, Audrey R. Tyrka, Lauren M. Wier, Andrea F. Mello, Marcelo F. Mello, George M. Anderson, Charles W. Wilkinson, Lawrence H. Price, Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment Biological Psychiatry. ,vol. 62, pp. 1080- 1087 ,(2007) , 10.1016/J.BIOPSYCH.2007.05.002
R. Musil, M.J. Schwarz, M. Riedel, S. Dehning, A. Cerovecki, I. Spellmann, V. Arolt, N. Müller, Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression — No influence of celecoxib treatment Journal of Affective Disorders. ,vol. 134, pp. 217- 225 ,(2011) , 10.1016/J.JAD.2011.05.047
Thierry Calandra, Thierry Roger, Macrophage migration inhibitory factor: a regulator of innate immunity. Nature Reviews Immunology. ,vol. 3, pp. 791- 800 ,(2003) , 10.1038/NRI1200