Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space

作者: Hidenori Otera , Shigenori Ohsakaya , Zen-Ichiro Nagaura , Naotada Ishihara , Katsuyoshi Mihara

DOI: 10.1038/SJ.EMBOJ.7600614

关键词: CytoplasmApoptosis-inducing factorTransport proteinCell biologyInner membraneProgrammed cell deathBiologyIntermembrane spaceMitochondrial intermembrane spaceMitochondrion

摘要: … To confirm the presequence processing site, we compared the molecular sizes of mature AIF in the mitochondria prepared from rat liver and HeLa cells with that of AIFΔN101, lacking …

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