Role of Cell Death Ligand and Receptor System on Regulation of Follicular Atresia in Pig Ovaries

摘要: Contents Several hundred thousand primordial follicles are present in the mammalian ovary, however, only a limited number develop to pre-ovulatory stage, and then finally ovulate. The others, more than 99%, will be eliminated through degenerative process called ‘atresia’. endocrinological regulatory mechanisms involved follicular development atresia have been characterized large extent, but precise temporal molecular regulation of these events remained unknown. From many recent studies, it is suggested that apoptosis ovarian granulosa cells plays crucial role atresia. Notably, death ligand–receptor interaction subsequent intracellular signalling demonstrated key regulating cell apoptosis. In this review, we provide an overview regulated by signalling. roles ligands receptors [Fas ligand (FasL)–Fas, tumour necrosis factor (TNF)α–TNF receptor (TNFR), TNFα-related apoptosis-inducing (TRAIL)–TRAIL (TRAILR)] death-signal mediators [Fas-associated domain protein (FADD), TNF 1-associated (TRADD), caspases, apoptotic protease-activating 1 (Apaf1), TNFR-associated 2 (TRAF2), cellular FLICE-like inhibitory (cFLIP), etc.] discussed.