Malignant hyperthermia in a liver transplant patient: a case report.

作者: C.R. Fernandes , D.M. Azevedo , J.M. Gomes , B.P. Gonçalves , G.R. Coelho

DOI: 10.1016/J.TRANSPROCEED.2007.09.036

关键词: ComplicationAnesthesiaPenetranceIsofluraneGraft dysfunctionSurgeryDantroleneMalignant hyperthermiaVariable ExpressionMedicineTransplant patient

摘要: Malignant hyperthermia is an autosomal dominant disorder with incomplete penetrance and variable expression. This syndrome characterized by a hypermetabolic response to all commonly used inhalational anesthetics depolarizing muscle relaxants. It can happen during or after the anesthesia. We describe case of malignant orthotopic liver transplantation. Our patient was 48-year-old man, born in Brazil but European ascendance, who developed associated use isoflurane. He treated dantrolene, which caused hepatic graft dysfunction. important that transplant teams be able recognize treat this complication.

参考文章(13)
Pearl L. Peters, Laszlo Endrenyi, Francis H. -F. Kwong, Beverley A. Britt, Ljiljana Kadijevic, Screening of malignant hyperthermia susceptible families by creatine phosphokinase measurement and other clinical investigations. Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 23, pp. 263- 284 ,(1976) , 10.1007/BF03005702
Alla D. Lyfenko, Sanjeewa A. Goonasekera, Robert T. Dirksen, Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease Biochemical and Biophysical Research Communications. ,vol. 322, pp. 1256- 1266 ,(2004) , 10.1016/J.BBRC.2004.08.031
Julian Loke, David H. MacLennan, Malignant hyperthermia and central core disease: disorders of Ca2+ release channels. The American Journal of Medicine. ,vol. 104, pp. 470- 486 ,(1998) , 10.1016/S0002-9343(98)00108-9
Benedikt H. J. Pannen, New insights into the regulation of hepatic blood flow after ischemia and reperfusion. Anesthesia & Analgesia. ,vol. 94, pp. 1448- 1457 ,(2002) , 10.1097/00000539-200206000-00012
Z Ben-Ari, Intrahepatic cholestasis after liver transplantation Liver Transplantation. ,vol. 9, pp. 1005- 1018 ,(2003) , 10.1053/JLTS.2003.50212
D.W. THOMAS, V.J. DEV, M.J. WHITEHEAD, MALIGNANT HYPERPYREXIA AND ISOFLURANE: A Case Report BJA: British Journal of Anaesthesia. ,vol. 59, pp. 1196- 1198 ,(1987) , 10.1093/BJA/59.9.1196
Annette Schmidt, Irene Tzanova, Andrea M.K. Köbler, Gregor J.F. Wisser, Rainer Kentner, Orthotopic liver transplantation in a malignant hyperthermia susceptible patient Journal of Clinical Anesthesia. ,vol. 17, pp. 558- 561 ,(2005) , 10.1016/J.JCLINANE.2004.11.005
Nicola Pierobon, Dominique C. Renard-Rooney, Lawrence D. Gaspers, Andrew P. Thomas, Ryanodine receptors in liver Journal of Biological Chemistry. ,vol. 281, pp. 34086- 34095 ,(2006) , 10.1074/JBC.M607788200