Racial disparities in molecular subtypes of endometrial cancer.
作者： Elizabeth A Dubil , Chunqiao Tian , Guisong Wang , Christopher M Tarney , Nicholas W Bateman
DOI: 10.1016/J.YGYNO.2017.12.009
关键词: Cancer genome 、 Histology 、 Racial differences 、 Advanced stage 、 Hazard ratio 、 Internal medicine 、 Medicine 、 Endometrial cancer 、 Copy Number Alteration 、 Oncology 、 Copy-number variation
摘要: Abstract Objectives Racial differences in the molecular subtypes of endometrial cancer and associations with progression-free survival (PFS) were evaluated. Methods Molecular, clinical PFS data acquired from Cancer Genome Atlas (TCGA) including classification into integrative, somatic copy number alteration transcript-based subtypes. The prevalence prognostic value aggressive (copy variant [CNV]-high, cluster 4 or mitotic) evaluated Black White patients. Results There 337 patients 14% self-designated as Black, 27% advanced stage, 82% endometrioid histology. CNV-high subtype was more common than (61.9% vs. 23.5%, P=0.0005) suggested worse (hazard ratio [HR]=3.4, P=0.189). prevalent (56.8% 20.9%, P Conclusions TCGA indicated both mitotic also Enrichment patterns signaling may represent therapeutic opportunities.
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