Immunohistochemical recognition of human nerve sheath tumors by anti-Leu 7 (HNK-1) monoclonal antibody.
作者： E. Perentes , L. J. Rubinstein
DOI: 10.1007/BF00690835
关键词: Schwannoma 、 Myelin-associated glycoprotein 、 Immunohistochemistry 、 Antibody 、 Neurofibroma 、 Biology 、 Schwann cell 、 Pathology 、 Monoclonal antibody 、 Nerve sheath neoplasm
摘要: Using relatively high dilutions of anti-Leu 7 monoclonal antibody and a four-step peroxidase-antiperoxidase (PAP) reaction in paraffin-embedded tissues, we tested the affinity this to cells 47 human nerve sheath tumors 22 other which differential diagnosis with neoplasms is known arise. Of all studied 68%, including 80% schwannomas, contained 7-positive cells. All non-schwannian were entirely, negative. Specimens eight experimental malignant rat schwannomas also negative for antibody. Our findings suggest that promising marker may facilitate between Schwann cell non-schwann neoplasms.
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sci-hub.se 参考文章(41)
S W Weiss, J M Langloss, F M Enzinger, Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors Laboratory Investigation. ,vol. 49, pp. 299- 308 ,(1983)
Claus Meier, Marc Vandevelde, Andreas Steck, Andreas Zurbriggen, Demyelinating polyneuropathy associated with monoclonal IgM-paraproteinaemia Journal of the Neurological Sciences. ,vol. 63, pp. 353- 367 ,(1984) , 10.1016/0022-510X(84)90159-X
PA Jr Bunn, I Linnoila, JD Minna, D Carney, AF Gazdar, Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells. Blood. ,vol. 65, pp. 764- 768 ,(1985) , 10.1182/BLOOD.V65.3.764.764
Charles M Balch, T. Abo, A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). Journal of Immunology. ,vol. 127, pp. 1024- 1029 ,(1981)
R Wollmann, M Jerkovic, K Stefansson, S-100 Protein in Soft-Tissue Tumors Derived From Schwann Cells and Melanocytes American Journal of Pathology. ,vol. 106, pp. 261- 268 ,(1982)
Lucien Jules Rubinstein, Dorothy S. Russell, Pathology of tumours of the nervous system ,(1977)
Andreas J. Steck, Norman Murray, Marc Vandevelde, Andreas Zurbriggen, Human monoclonal antibodies to myelin-associated glycoprotein: Comparison of specificity and use for immunocytochemical localisation of the antigen Journal of Neuroimmunology. ,vol. 5, pp. 145- 156 ,(1983) , 10.1016/0165-5728(83)90005-X
H B Coakham, J A Garson, Betty Brownell, J T Kemshead, Monoclonal antibodies as reagents for brain tumour diagnosis: a review. Journal of the Royal Society of Medicine. ,vol. 77, pp. 780- 787 ,(1984) , 10.1177/014107688407700914
Jose M. Bonnin, Lucien J. Rubinstein, Immunohistochemistry of central nervous system tumors. Its contributions to neurosurgical diagnosis. Journal of Neurosurgery. ,vol. 60, pp. 1121- 1133 ,(1984) , 10.3171/JNS.1984.60.6.1121
E. Nobile-Orazio, A. P. Hays, N. Latov, G. Perman, J. Golier, M. E. Shy, L. Freddo, Specificity of mouse and human monoclonal antibodies to myelin‐associated glycoprotein Neurology. ,vol. 34, pp. 1336- 1336 ,(1984) , 10.1212/WNL.34.10.1336