Depletion of Neutrophils by Filter During Aortocoronary Bypass Surgery Transiently Improves Postoperative Cardiorespiratory Status
作者： David Johnson , Dorothy Thomson , Taras Mycyk , Brian Burbridge , Irvin Mayers
关键词: Filter (video) 、 Derivation 、 Coronary artery bypass surgery 、 Cardiopulmonary bypass 、 Medicine 、 Hemodynamics 、 Anesthesia 、 White blood cell 、 Extracorporeal 、 Cardiorespiratory fitness 、 Critical Care and Intensive Care Medicine 、 Pulmonary and Respiratory Medicine 、 Cardiology and Cardiovascular Medicine
摘要: Study objective To determine whether inclusion of a leukocyte specific filter into the extracorporeal circuit during aortocoronary bypass surgery alters postoperative cardiopulmonary function. Design Randomized, double-blinded control trial. Setting Tertiary care hospital. Patients Convenience sampling patients undergoing elective between October 1992 and June 1993. Interventions A total 32 were randomized to (n=16) or standard blood surgical procedure. Measurements results White cell count in group (12.2 ±3.6 10 9 /L) was higher (p=0.047) than (9.9±2.6 at 4 h postoperatively but counts similar (p=0.063) 24 (10.8 ±2.7 vs 8.9±2.6 /L, respectively). Leukocyte activation assessed by chemiluminescence groups all measurement periods. We noted transient improvements (p Conclusions Inclusion caused cardiorespiratory improvement that lost within did not offer any significant clinical benefits.
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