Interleukin-6 (IL-6) as a mediator of stunned myocardium

摘要: Abstract Proinflammatory cytokines are a class of secretory polypeptides that synthesized and released locally by macrophages, leukocytes endothelial cells in response to injury. 1–4 Reperfusion ischemic myocardium is associated with infiltration macrophages may be responsible for transient depression myocardial contractility (“stunned myocardium”). 1,2 We have recently demonstrated certain (IL-2, IL-6, TNFα) direct, reversible negative inotropic effects isolated hamster papillary muscle preparations. 5 The observed these raised the possibility they contribute stunning. A direct effect on human concentrations achievable clinically would necessary further support this hypothesis. frequency stunning after cardiopulmonary bypass provided an ideal opportunity assay levels as well hearts. Written, informed consent was obtained from patients undergoing elective aortocoronary grafting accordance guidelines University Pittsburgh Institutional Review Board Biomedical Research. elaboration pulmonary injury suggested venous blood might rich source inflammatory bypass. 6 Plasma TNFα IL-6 effluents were measured 7 immediately before uncomplicated coronary artery grafting.