LRRfinder2.0: A webserver for the prediction of leucine-rich repeats:
作者： Victoria Offord , Dirk Werling
关键词: Phylogenetic tree 、 Genetics 、 Biology 、 Leucine-rich repeat 、 Innate immune system 、 Toll-like receptor 、 Amino acid
摘要: Leucine-rich repeats (LRRs) are versatile motifs present in more than 6000 proteins throughout the phylogenetic kingdom. Tandem LRRs generate a characteristic horseshoe with diverse range of functions. Fulfilling key role innate immune system, form TLR and NOD-like receptor (NLR) pathogen-recognition domain. Host–pathogen interactions mediated by drive those involved ligand recognition to become distinct from their consensus motif. Most between 21 30 residues; however, large insertions certain TLRs can over 60 amino acids. LRR variability makes them ideal for species-specific mediation host-pathogen interactions. Teleost show insertions, making cross-species alignments difficult without prior demarcation motifs. We LRRfinder2.0, webserver prediction. LRRfinder2.0 utilizes scoring matrices comprising 60,000 200 species. The underlying database tLRRdb contain...
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