Amphiphilic depsipeptide‐based block copolymers as nanocarriers for controlled release of ibuprofen with doxorubicin

摘要: Well-defined amphiphilic multiblock copolymers PDMAEMA-b-P(IBMD-co-PDO)-b-PEG-b-P(IBMD-co-PDO)-b-PDMAEMA [PDMAEMA-PIBMD-PPDO-PEG], based on poly(2-(dimethylamino)ethyl methacrylate) block (PDMAEMA), poly(3(S)-isobutyl-morpholine-2,5-dione-co-p-dioxanone) (P(IBMD-co-PDO)), and poly(ethylene glycol) (PEG) were successfully synthesized by combination of ring-opening polymerization (using 3(S)-isobutyl-morpholine-2,5-dione p-dioxanone initiated hydroxyl end PEG) atom transfer radical (ATRP). Furthermore, all these characterized 1H NMR, 13C Fourier transformed-infrared, gel permeation chromatography, differential scanning calorimetry, thermogravimetric analysis measurements. The degradation experiments showed that the molecular weight PDMAEMA-PIBMD-PPDO-PEG decreased along with time. In addition, could readily self-assemble into nanosized microspheres in phosphate buffered solution. Ibuprofen (IBU) doxorubicin (DOX) as a kind combined model drugs loaded ionic interaction hydrophobic effect. These copolymer exhibited high loading capacity (LC, up to 26.88%), encapsulation efficiency (EE, 61.29%), sustained release behavior IBU–DOX results transmission electron microscopy dynamic light scattering well-defined uniform spherical particles average diameter less than 120 nm. Therefore, it can be envisaged systems are promising candidates for controlled application. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Chem. 2013, 51, 3213–3226