Chemotactic signaling in mesenchymal cells compared to amoeboid cells

摘要: Cell chemotaxis plays a pivotal role in normal development, inflammatory response, injury repair and tissue regeneration all organisms. It is also critical contributor to cancer metastasis, altered angiogenesis neurite growth disease. The molecular mechanisms regulating are currently being identified key components may be pertinent therapeutic targets. Although these appear mostly common various cells, there important differences chemotactic signaling networks signal processing that result the distinct behavior of mesenchymal cells compared much better studied amoeboid blood cells. These not necessarily predetermined based on cell type, but rather chosen exploited by modify their physical constraints and/or environmental conditions. This results specific type migration can selectively targeted Here, we compare behavior, motility We suggest current model applicable for small needs reconsidered large focus new candidate regulatory molecules feedback account type-specific chemotaxis.