Effects of 3D Geometries on Cellular Gradient Sensing and Polarization

摘要: During cell migration, cells become polarized, change their shape, and move in response to various internal external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, determined by intracellular signaling networks. It results directional forces actin polymerization myosin contractions. Many existing mathematical models are formulated terms reaction-diffusion systems interacting molecules, often one two spatial dimensions. In this paper, we introduce a 3D model single cell, find that geometry has an important role affecting capability polarize, when signal changes direction. Our suggest geometrical argument why more roundish can repolarize effectively than which elongated along direction original stimulus, thus enable turn faster, been observed experiments. On other hand, preferentially polarize main axis even gradient stimulus appears from another Furthermore, our accurately capture effect binding unbinding regulators membrane. This separation membrane cytosol, not possible 1D 2D models, leads marked differences comparable lower-dimensional models.