The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial.
作者： Kazem Nouri , Katharina Walch , Andrea Weghofer , Martin Imhof , Christian Egarter
DOI: 10.1159/000452662
关键词: Intracytoplasmic sperm injection 、 Embryo transfer 、 Andrology 、 Micronutrient 、 Pregnancy rate 、 Vitamin E 、 In vitro fertilisation 、 Pregnancy 、 Embryo quality 、 Medicine
摘要: The role of micronutrients in fertility has recently gained increased attention. We aimed to test the impact a standardized, multinutrient supplementation on outcomes after vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) pilot study. One hundred women undergoing IVF/ICSI were prospectively included and randomized receive either named PROfertil® female that folic acid, selenium, vitamin E, catechins, glycyrrhizin, diosgenin, damiana omega-3-fatty acids (study group; n = 50), or 400 µg acid (control 50). Outcome parameters embryo quality day 3 oocyte retrieval (good vs. poor quality) clinical pregnancy rate. In an intention-to-treat analyses, higher rate with at least one good (with 6 cells fragmentation <20%) found for study (29/50, 58.0%) compared control group (18/50, 36.0%; p 0.045 chi-square test; relative risk 1.611, 95% CI 1.009-2.597). conclusion, includes seems beneficial terms quality.
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