Identification of Hot and Cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts

摘要: The organization of genomic sequences is dynamic and undergoes change during the process evolution. Many variations arise spontaneously observed changes can either be distributed uniformly throughout genome or preferentially localized to some regions (hot spots) compared others. Conversely cold spots may tend accumulate very few none at all. In order identify such statistically, we have developed a method based on Shewhart Control Chart. was used for identification hot single-nucleotide (SNVs) in Mycobacterium tuberculosis genomes. predictions been validated by sequencing these derived from clinical isolates. This analysis other particularly infectious microbes.