Genotype to phenotype: a complex problem.
作者： R. D. Dowell , O. Ryan , A. Jansen , D. Cheung , S. Agarwala
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摘要: We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Σ1278b, Saccharomyces cerevisiae strain closely related to reference S288c. Similar the variation between human individuals, Σ1278b S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant phenotypes identified subset that were conditionally essential by strain, including 44 unique 13 Genetic analysis indicates conditional phenotype was most often governed complex genetic interactions, depending on multiple background-specific modifiers. Our comprehensive suggests presence set modifiers will underlie phenotypic differences individuals.
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