Chronic relapsing experimental allergic encephalomyelitis: morphological sequence of myelin degradation.

作者: H. Lassmann , H.M. Wisniewski

DOI: 10.1016/0006-8993(79)91036-9

关键词: Luxol fast blue stainMyelinEncephalomyelitisBiophysicsDegradation (geology)ChemistryLamellar structureExperimental allergicElectron microscopePathology

摘要: Summary Myelin degradation in chronic relapsing experimental allergic encephalomyelitis was studied using light microscopic histochemistry and electron microscopy. In the earliest stages, a large number of myelin stripping macrophages were found. The Luxol fast blue positive products then gradually transformed into PAS material. No sudanophilic stage found this model. microscopy, material identified as uniformly layered lipid inclusions with periodicity 4.0–4.5 nm. During further digestion, polymorph structured material, consisting lamellar leaflets diameter 7–10 nm, curved cylindrical profiles granular osmiophilic

参考文章(37)
M. R. Cressman, P. W. Lampert, Fine-structural changes of myelin sheaths after axonal degeneration in the spinal cord of rats. American Journal of Pathology. ,vol. 49, pp. 1139- 1155 ,(1966)
R.H.M. Ballin, P.K. Thomas, Electron microscope observations on demyelination and remyelination in experimental allergic neuritis Journal of the Neurological Sciences. ,vol. 8, pp. 1- 18 ,(1969) , 10.1016/0022-510X(69)90037-9
H. Lassmann, H. M. Wisniewski, Chronic relapsing EAE time course of neurological symptoms and pathology Acta Neuropathologica. ,vol. 43, pp. 35- 42 ,(1978) , 10.1007/BF00684996
CEDRIC S. RAINE, MURRAY B. BORNSTEIN, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS Journal of Neuropathology and Experimental Neurology. ,vol. 29, pp. 177- 191 ,(1970) , 10.1097/00005072-197004000-00002
J. F. Hallpike, C. W. M. Adams, O. B. Bayliss, Histochemistry of myelin. IX. Neutral and acid proteinases in early Wallerian degeneration. Histochemical Journal. ,vol. 2, pp. 209- 218 ,(1970) , 10.1007/BF01003470
Marvin W. Luttges, Paul T. Kelly, Richard A. Gerren, Degenerative changes in mouse sciatic nerves: electrophoretic and electrophysiologic characterizations. Experimental Neurology. ,vol. 50, pp. 706- 733 ,(1976) , 10.1016/0014-4886(76)90039-X
J. J. Hauw, R. Escourolle, Filamentous and multilamellated cytoplasmic inclusions in progressive multifocal leukoencephalopathy. Acta Neuropathologica. ,vol. 37, pp. 263- 265 ,(1977) , 10.1007/BF00686889