Safety of Outpatient Parenteral Antimicrobial Therapy in Children.

作者: Priyanka Fernandes , Carly Milliren , Helen M. Mahoney-West , Laura Schwartz , Catherine S. Lachenauer

DOI: 10.1097/INF.0000000000001716

关键词: Intensive care medicineRetrospective cohort studyCohort studyObservational studyMedicineAntimicrobialMEDLINE

摘要: Background and Objective: Outpatient parenteral antimicrobial therapy (OPAT) provides numerous benefits but may pose unique risks in children. We aimed to determine rates of OPAT antimicrobial-and intravenous access-related complications and their associations with specific antimicrobials and type of intravenous access in pediatric patients. Methods: Observational cohort study of patients receiving OPAT from August 2008 to May 2015 cared for by the Infectious Diseases service at a tertiary children's hospital. Primary outcome was …

参考文章(16)
Boeun Lee, Idy Tam, Bernard Weigel, Janis L. Breeze, Jessica K. Paulus, Jason Nelson, Genève M. Allison, Comparative outcomes of β-lactam antibiotics in outpatient parenteral antibiotic therapy: treatment success, readmissions and antibiotic switches Journal of Antimicrobial Chemotherapy. ,vol. 70, pp. 2389- 2396 ,(2015) , 10.1093/JAC/DKV130
Sonia N. Rao, Nathaniel J. Rhodes, Benjamin J. Lee, Marc H. Scheetz, Amy P. Hanson, John Segreti, Christopher W. Crank, Sheila K. Wang, Treatment Outcomes with Cefazolin versus Oxacillin for Deep-Seated Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections Antimicrobial Agents and Chemotherapy. ,vol. 59, pp. 5232- 5238 ,(2015) , 10.1128/AAC.04677-14
Jason D. Fraser, Pablo Aguayo, Charles M. Leys, Scott J. Keckler, Jason G. Newland, Susan W. Sharp, John P. Murphy, Charles L. Snyder, Ronald J. Sharp, Walter S. Andrews, George W. Holcomb, Daniel J. Ostlie, Shawn D. St. Peter, A complete course of intravenous antibiotics vs a combination of intravenous and oral antibiotics for perforated appendicitis in children: a prospective, randomized trial Journal of Pediatric Surgery. ,vol. 45, pp. 1198- 1202 ,(2010) , 10.1016/J.JPEDSURG.2010.02.090
P S Cannon, D Mc Keag, R Radford, S Ataullah, B Leatherbarrow, Our experience using primary oral antibiotics in the management of orbital cellulitis in a tertiary referral centre Eye. ,vol. 23, pp. 612- 615 ,(2009) , 10.1038/EYE.2008.44
MargaretL Hoffman-Terry, HenryS Fraimow, TimothyR Fox, BrianG Swift, JudithE Wolf, Adverse effects of outpatient parenteral antibiotic therapy. The American Journal of Medicine. ,vol. 106, pp. 44- 49 ,(1999) , 10.1016/S0002-9343(98)00362-3
Theresa Madigan, Ritu Banerjee, Characteristics and outcomes of outpatient parenteral antimicrobial therapy at an academic children's hospital. Pediatric Infectious Disease Journal. ,vol. 32, pp. 346- 349 ,(2013) , 10.1097/INF.0B013E31827EE1C2
Offie P. Soldin, Donald R. Mattison, Sex Differences in Pharmacokinetics and Pharmacodynamics Clinical Pharmacokinectics. ,vol. 48, pp. 143- 157 ,(2009) , 10.2165/00003088-200948030-00001
Eric Macy, T. Poon K-Y, Self-reported Antibiotic Allergy Incidence and Prevalence: Age and Sex Effects The American Journal of Medicine. ,vol. 122, pp. 7- 8 ,(2009) , 10.1016/J.AMJMED.2009.01.034
Margarita Gomez, Nizar Maraqa, Ana Alvarez, Mobeen Rathore, Complications of outpatient parenteral antibiotic therapy in childhood. Pediatric Infectious Disease Journal. ,vol. 20, pp. 541- 543 ,(2001) , 10.1097/00006454-200105000-00015