Pre- and Post-synaptic Effects of Botulinum Toxin A on Submandibular Glands
作者： H. Xu , X.F. Shan , X. Cong , N.Y. Yang , L.L. Wu
关键词: Chemistry 、 Secretion 、 Transfection 、 Internal medicine 、 Blot 、 Submandibular gland 、 Inhibitory postsynaptic potential 、 Endocrinology 、 Sialorrhea 、 Saliva 、 Salivary gland
摘要: Intraglandular injection of botulinum toxin type A (BoNT/A) is an effective treatment for sialorrhea. Despite numerous experimental and clinical studies on inhibition saliva section by BoNT/A, the proteolysis synaptosomal-associated protein 25 (SNAP-25) following BoNT/A has not yet been confirmed in salivary gland after BoNT/A. More important, it known whether exerts a direct effect acinar cells. Here, we show that into rat submandibular (SMG) decreased flow dose-dependent manner; inhibitory lasted at least 4 wk, recovered to normal levels 12 wk. During period, SMG neurons synapses expressed lower full-length SNAP-25, cleavage SNAP-25 was observed, as indicated detection reduced molecular weight using Western blotting. In addition, water channel aquaporin 5 (AQP5) downregulated abnormally distributed inj...
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