Extracellular Vesicle-Mediated Cell⁻Cell Communication in the Nervous System: Focus on Neurological Diseases.

摘要: Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They involved in cell differentiation, tissue homeostasis, and organ remodelling virtually all tissues, central nervous system (CNS). secreted a range of types via blood reaching other whose functioning they can modify because transport deliver active molecules, such as proteins various functions, lipids, DNA, miRNAs. Since relatively easy to isolate, exosomes be characterized, their composition elucidated manipulated bioengineering techniques. Consequently, appear promising theranostics elements, applicable accurately diagnosing pathological conditions, assessing prognosis response treatment variety disorders. Likewise, characteristics manageability make them potential candidates for delivering selected e.g., therapeutic drugs, specific target tissues. All these possible applications pertinent research neurophysiology, well study neurological disorders, CNS tumors, autoimmune neurodegenerative diseases. In this brief review, we discuss what is known about role future its diseases, focusing on cell–cell communication physiology pathology.