Induction of acute and chronic arthritis by intra-articular injection of preformed collagen-anticollagen complexes.

摘要: Three groups of rabbits were injected intra-articularly into the knee joints with preformed complexes hydroxamated collagen and antiserum to denatured respectively, normal serum, collagen, anticollagen serum or saline as controls. From twelve rabbits, receiving only one injection investigated 8 h later, joint tissues which received immune showed acute arthritis severe infiltration polymorphonuclears, leucocyte thrombi in vessels haemorrhages. six two consecutive injections (day 0 day 2) 12 after last injection, tissue subacute-chronic arthritis. sixteen four 0, 2, 7 14) days chronic plasma cells, lymphocytes nodule-like accumulation whilst their fluid additionally a distinctly increased number polymorphonuclears (3-15 x 10(6)) differed P less than 0-01 statistically from all