Skin Aging from Ultraviolet Irradiance and Smoking Reduces Risk of Melanoma: Epidemiological Evidence

摘要: Long-term smoking appears to be inversely correlated with development of melanoma. Chronic ultraviolet (UV) irradiance also reduces and/or delays the Thus, a common process is indicated. To examine link between and melanoma, articles reporting relation incidence lung cancer melanoma for individuals were sought .A very strong inverse correlation (r=-0.96) was found standardized ratios passing through value 1 each slope -0.74. Smoking increases skin aging or elastosis in manner similar that UV irradiance. Development seems explain why long-term chronic reduce risk Further work required elucidate mechanism whereby retards The connection intriguing. Most studies have reported measures (Table I). No suggestions been made what might these observations. situation contrasts basal cell carcinoma (BCC) squamous (SCC), which factor (3, 6-13). In addition, body sites subject solar develop later life than do sporadic irradiance, as shown study respect site, age, period. 1960-1964, site intermittent trunk, had highest rates men aged 30-49 years, whereas continuous head neck, women older 50 years (14). Similar results British Columbia (15). These suggest processes associated decrease This conclusion not, however, not significant Several UVA (320- 400 nm) an important (16-20), recent review summarized evidence sunlight (21). However, by age indicate there may explaining goal this propose evaluate could