Interaction of fibroblast with poly(p-dioxanone) and its degradation products
作者： M. A. Sabino , J. L. Feijoo , O. Nuñez , D. Ajami
关键词: Materials science 、 Fibroblast 、 Biomaterial 、 Polymer chemistry 、 Cell adhesion 、 Adhesion 、 Biophysics 、 Matrix (biology) 、 Cell growth 、 Biocompatibility 、 Cell damage
摘要: In vitro techniques were used to evaluate the interactions between Fibroblastic cells and Poly(p-Dioxanone) PPDX compared its performance with that of other polymeric substrates. biocompatibility was assessed by studying cell adhesion growth on polymer films themselves as well in media enriched degradation products Poly(glycolic)/Poly(L-lactide 90:10 copolymer (PGLA-910). Our results show althought all polymers tested suitable for initial attachment, proved be most favorable surface growth; density after 48 h culture similar obtained tissue Polystyrene TCPS (control). No signs damage detected using scanning electron microscopy (SEM) where h. seeding PPDX, fibroblast exhibited a confluent multilayer TCPS. addition, hydrolytic had no citotoxic effect adherence proliferation fibroblastic The starts amorphous regions, tie-chain segments these regions degrade into fragments causing pH decrease buffer solution weight loss degradable polymers. evaluation suggests may candidate biomaterial construction cell-polymer matrix.
springer.com
sci-hub.se 参考文章(16)
D. Muster, Biomaterials: Hard Tissue Repair and Replacement ,(1992)
Hsing-Wen Sung, Chin-Sheng Hsu, Yuag-Shein Lee, Der-Shyu Lin, Crosslinking characteristics of an epoxy-fixed porcine tendon: effects of pH, temperature, and fixative concentration. Journal of Biomedical Materials Research. ,vol. 31, pp. 511- 518 ,(1996) , 10.1002/(SICI)1097-4636(199608)31:4<511::AID-JBM11>3.0.CO;2-J
X.F. Walboomers, H.J.E. Croes, L.A. Ginsel, J.A. Jansen, Contact guidance of rat fibroblasts on various implant materials. Journal of Biomedical Materials Research. ,vol. 47, pp. 204- 212 ,(1999) , 10.1002/(SICI)1097-4636(199911)47:2<204::AID-JBM10>3.0.CO;2-H
Jeffrey S. Burmeister, Valerie Z. McKinney, William M. Reichert, George A. Truskey, Role of endothelial cell-substrate contact area and fibronectin-receptor affinity in cell adhesion to HEMA/EMA copolymers. Journal of Biomedical Materials Research. ,vol. 47, pp. 577- 584 ,(1999) , 10.1002/(SICI)1097-4636(19991215)47:4<577::AID-JBM15>3.0.CO;2-S
C. Morrison, R. Macnair, C. MacDonald, A. Wykman, I. Goldie, M.H. Grant, In vitro biocompatibility testing of polymers for orthopaedic implants using cultured fibroblasts and osteoblasts Biomaterials. ,vol. 16, pp. 987- 992 ,(1995) , 10.1016/0142-9612(95)94906-2
Wei-Bor Tsai, Thomas A. Horbett, The role of fibronectin in platelet adhesion to plasma preadsorbed polystyrene. Journal of Biomaterials Science-polymer Edition. ,vol. 10, pp. 163- 181 ,(1999) , 10.1163/156856299X00117
D. F. Williams, Biodegradation of surgical polymers Journal of Materials Science. ,vol. 17, pp. 1233- 1246 ,(1982) , 10.1007/BF00752233
B. Saad, T. D. Hirt, M. Welti, G. K. Uhlschmid, P. Neuenschwander, U. W. Suter, Development of degradable polyesterurethanes for medical applications: In vitro and in vivo evaluations Journal of Biomedical Materials Research. ,vol. 36, pp. 65- 74 ,(1997) , 10.1002/(SICI)1097-4636(199707)36:1<65::AID-JBM8>3.0.CO;2-J
N. Peppas, R Langer, New challenges in biomaterials Science. ,vol. 263, pp. 1715- 1720 ,(1994) , 10.1126/SCIENCE.8134835
Yasushi Tamada, Yoshito Ikada, Fibroblast growth on polymer surfaces and biosynthesis of collagen. Journal of Biomedical Materials Research. ,vol. 28, pp. 783- 789 ,(1994) , 10.1002/JBM.820280705