Multiple connections link FAK to cell motility and invasion.

作者: David D Schlaepfer , Satyajit K Mitra

DOI: 10.1016/J.GDE.2003.12.002

关键词: PhosphorylationFocal adhesionBiologyGrowth factorSignal transductionCell biologyIntegrinMotilityIntracellularExtracellular

摘要: The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual proteins must act integrators, responding multiple extracellular inputs and regulating pathway outputs. In this review, we highlight recent findings place focal adhesion kinase (FAK) in an important receptor-proximal position the regulation growth factor integrin-stimulated motility. Emphasis is placed on molecular mechanisms FAK activation, connections contact formation well turnover, potential function promoting invasion may be distinct from its role

参考文章(69)
Candece L Gladson, Focal adhesion kinase in cancer. Frontiers in Bioscience. ,vol. 8, ,(2003) , 10.2741/1115
Guan Jl, Abbi S, Focal adhesion kinase: protein interactions and cellular functions. Histology and Histopathology. ,vol. 17, pp. 1163- 1171 ,(2002) , 10.14670/HH-17.1163
Veronica Gabarra-Niecko, FAK regulates biological processes important for the pathogenesis of cancer. Cancer and Metastasis Reviews. ,vol. 22, pp. 359- 374 ,(2003) , 10.1023/A:1023725029589
Steven K Hanks, Larisa Ryzhova, Nah-Young Shin, Jan Brábek, Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Frontiers in Bioscience. ,vol. 8, ,(2003) , 10.2741/1114
David J. Sieg, Christof R. Hauck, Dusko Ilic, Candice K. Klingbeil, Erik Schaefer, Caroline H. Damsky, David D. Schlaepfer, FAK integrates growth-factor and integrin signals to promote cell migration Nature Cell Biology. ,vol. 2, pp. 249- 256 ,(2000) , 10.1038/35010517
Riyan Chen, Oekyung Kim, Ming Li, Xinsheng Xiong, Jun-Lin Guan, Hsing-Jien Kung, Hegang Chen, Yoji Shimizu, Yun Qiu, Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain Nature Cell Biology. ,vol. 3, pp. 439- 444 ,(2001) , 10.1038/35074500
Christof R. Hauck, Datsun A. Hsia, Dusko Ilic, David D. Schlaepfer, v-Src SH3-enhanced Interaction with Focal Adhesion Kinase at β1Integrin-containing Invadopodia Promotes Cell Invasion Journal of Biological Chemistry. ,vol. 277, pp. 12487- 12490 ,(2002) , 10.1074/JBC.C100760200
Hui Miao, Elisabeth Burnett, Michael Kinch, Erin Simon, Bingcheng Wang, Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation Nature Cell Biology. ,vol. 2, pp. 62- 69 ,(2000) , 10.1038/35000008
Smita Abbi, Hiroki Ueda, Chuanhai Zheng, Lee Ann Cooper, Jihe Zhao, Renee Christopher, Jun-Lin Guan, Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200 Molecular Biology of the Cell. ,vol. 13, pp. 3178- 3191 ,(2002) , 10.1091/MBC.E02-05-0295