Transferrin receptors in injured brain

作者: T. Orita , T. Akimura , T. Nishizaki , T. Kamiryo , Y. Ikeyama

DOI: 10.1007/BF00294248

关键词: PathologyTransferrin receptorAstrocyteReceptorImmunohistochemistryEndothelial stem cellTransferrinLesionCentral nervous systemBiology

摘要: Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in central nervous system. The present study Wistar rats with experimentally induced brain injuries, using immunohistochemistry at light microscopy level, Tf-R regenerated endothelial cells, reactive astrocytes and other probably macrophages. Although were seen proliferating also observed nonproliferating many them perhaps bind edema fluid play an important role lesion repair.

参考文章(14)
Robert M. Galbraith, Phillip Werner, Philippe Arnaud, Gillian M. P. Galbraith, Transferrin Binding to Peripheral Blood Lymphocytes Activated by Phytohemagglutinin Involves a Specific Receptor: LIGAND INTERACTION Journal of Clinical Investigation. ,vol. 66, pp. 1135- 1143 ,(1980) , 10.1172/JCI109943
Bradbury Mw, The structure and function of the blood-brain barrier. Federation proceedings. ,vol. 43, pp. 186- ,(1984)
A. Dautry-Varsat, A. Ciechanover, H. F. Lodish, pH and the recycling of transferrin during receptor-mediated endocytosis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 2258- 2262 ,(1983) , 10.1073/PNAS.80.8.2258
Toshihiko Miyake, Takanori Hattori, Masaru Fukuda, Tadahisa Kitamura, Setsuya Fujita, Quantitative studies on proliferative changes of reactive astrocytes in mouse cerebral cortex Brain Research. ,vol. 451, pp. 133- 138 ,(1988) , 10.1016/0006-8993(88)90757-3
Araceli Espinosa de los Monteros, Bernard Foucaud, Effect of iron and transferrin on pure oligodendrocytes in culture; characterization of a high-affinity transferrin receptor at different ages. Developmental Brain Research. ,vol. 35, pp. 123- 130 ,(1987) , 10.1016/0165-3806(87)90014-9
Wilfred A. Jefferies, Malcolm R. Brandon, Simon V. Hunt, Alan F. Williams, Kevin C. Gatter, David Y. Mason, Transferrin receptor on endothelium of brain capillaries Nature. ,vol. 312, pp. 162- 163 ,(1984) , 10.1038/312162A0
W. Page Faulk, Bae-Li Hsi, P.J. Stevens, TRANSFERRIN AND TRANSFERRIN RECEPTORS IN CARCINOMA OF THE BREAST The Lancet. ,vol. 316, pp. 390- 392 ,(1980) , 10.1016/S0140-6736(80)90440-7
Adrian B. Bomford, Hamish N. Munro, Transferrin and its receptor: their roles in cell function. Hepatology. ,vol. 5, pp. 870- 875 ,(1985) , 10.1002/HEP.1840050528
John Zovickian, Virginia Gray Johnson, Richard J. Youle, Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin. Journal of Neurosurgery. ,vol. 66, pp. 850- 861 ,(1987) , 10.3171/JNS.1987.66.6.0850
Tetsuji Orita, Takafumi Nishizaki, Toshifumi Kamiryo, Kunihiko Harada, Hideo Aoki, Cerebral microvascular architecture following experimental cold injury. Journal of Neurosurgery. ,vol. 68, pp. 608- 612 ,(1988) , 10.3171/JNS.1988.68.4.0608