Activation of iron handling system within the gerbil hippocampus after cerebral ischemia.
作者： Hirohisa Ishimaru , Koichi Ishikawa , Yoshihide Ohe , Akira Takahashi , Kazuhiko Tatemoto
DOI: 10.1016/0006-8993(96)00294-6
关键词: Neuroglia 、 Astrocyte 、 Ischemia 、 Neuroscience 、 Microglia 、 Internal medicine 、 Endocrinology 、 Biology 、 Ferritin 、 Hippocampus 、 Gerbil 、 Transferrin
摘要: Analyzing the distribution pattern of transferrin (Tf) and ferritin, we investigated changes in iron metabolism related proteins process neuronal death induced by 5 min ischemia. In control animals, Tf immunoreactivity was localized oligodendrocytes. Ferritin distributed both neurons gliacytes, particularly microglia. parallel with delayed death, Tf-positive atrophied numerous ferritin-positive gliacytes appeared CA1 subfield hippocampus 4 days after ischemia, when glia fibrillary acidic protein (GFAP)-positive astrocytes also throughout hippocampal structure. A considerable number phagocytes (reactive microglia) stratum pyramidale from seventh day. Our data show clearly that mobilization are linked degeneration cerebral These events may suggest an activation handling system under postischemic condition.
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