Regulation of plasma atrial natriuretic peptide by the central nervous system

摘要: The anterior ventral region of the third ventricle (AV3V) is a major central site in regulation cardiovascular and renal function. To examine role nervous system atrial natriuretic peptide (ANP) secretion, effect lesions this on basal, volume-stimulated, osmotic-stimulated plasma ANP was determined. Basal levels were not different sham- AV3V-lesioned rats. Volume expansion with continuous infusion saline or bolus administration increased sham-lesioned In rats, had no ANP, decreased ANP. Osmotic stimulation hypertonic rats but These results suggest that involved secretion altered may contribute to deficiencies